Message from the Clinical Trials Director:

Welcome to the UW Ophthalmology Clinical Trials website and thank you for taking the time to learn about our Clinical Trials program and research opportunities.

We offer several clinical trials seeking to advance treatments for a variety of ocular conditions. Our clinician-scientists are also studying new ways to prevent, detect, or treat many sight-threatening conditions with the help of their patients. Clinical trials and research provide the foundations for important discoveries such as new drugs or devices, thus we cannot thank patients enough for their willingness to participate in our clinical trials and research studies.

Our study team is committed to making your participation enjoyable. Please contact our study team with any questions or to find out whether you are eligible for any of our current trials or research studies. On behalf of the study team, allow me to thank you for your interest in helping the field of ophthalmology move forward.

What is a clinical study?

A clinical study involves research using human volunteers and in general is designed to add to medical knowledge related to the treatment, diagnosis, and prevention of diseases or conditions.

Clinical Trials

A clinical trial, or research study, is the scientific term for a test or study of a drug, therapy, surgical procedure or medical device. The studies are performed to determined whether the drug, therapy, procedure, or medical device is effective for people to use.

In a clinical trial, participants receive specific interventions according to the research plan or protocol created by the investigators.  Clinical trials may compare a new medical approach to a standard one that is already available, to a placebo that contains no active ingredients, or to no intervention.  When a new product or approach is being studied, the goal is to determine whether it will be helpful, harmful, or no different than available alternatives (including no intervention). The investigators try to determine the safety and efficacy of the intervention by measuring certain outcomes in the participants.

We have a critical need for volunteers for these studies. If you are interested in participating in a clinical trial being run by the department of Ophthalmology please visit the participate tab above.

Why Participate?

Future medical discoveries are not possible without clinical research. And clinical research is not possible without volunteers. 

By taking part in research studies, you can try a potential new treatment that may (or may not) be better than standard treatments available. Your participation may also help people who may be suffering from the same disease or condition in the future. 

We have a critical need for volunteers for these studies.  Eighty-five percent of studies get started late and 40 percent never finish because of a shortage of volunteers.  Researchers are working hard to find new and better ways to treat diseases, but they need people like you to help contribute.

When you participate in a research study, you are helping to move research forward.  This means that cures and treatments are able to reach people more quickly.  You can help make history by participating in research. Working together, we can improve healthcare for years to come. Join us to improve the health of others.

Who Can Participate in a Clinical Study?

Clinical studies have standards outlining who can participate. These standards are called eligibility criteria and are listed in the protocol. Some research studies seek participants who have the illnesses or conditions that will be studied, other studies are looking for healthy participants, and some studies are limited to a predetermined group of people who are asked by researchers to enroll.

Eligibility. The factors that allow someone to participate in a clinical study are called inclusion criteria, and the factors that disqualify someone from participating are called exclusion criteria. They are based on characteristics such as age, gender, the type and stage of a disease, previous treatment history, and other medical conditions.

Current, active IRB approved, studies at University of Washington

Quark Study – Non Arteritic Anterior Ischemic Optic Neuropathy – NAION

This study will test the experimental drug, QPI-1007.  This drug is being developed to treat vision loss that can occur when there is not enough blood flow to the nerve tissue in the eye; that is, after a stroke of the optic nerve or NAION. If you are interested in this study please click here.

ASSISTS Study – The AGS Second Shunt Implant vs Transcleral Cyclophotocoagulation Treatment Study

The purpose of this study is to compare two different eye surgeries in patients who have uncontrolled glaucoma after having an aqueous shunt implant.  The two different glaucoma surgeries being compared are a second aqueous shunt implant and a diode laser cyclophotocoagulation.

OMAG Study – Non-invasive in vivo Optical imaging of Microstructural and Microvascular Tissues in the Eye

Optical Coherence Tomography (OCT) is a current method of taking three dimensional images of the eye.  Recently our research laboratory has developed a way to also see blood vessels and blood flow in the eye non-invasively.  The purpose of this study is to see if this new way of seeing the eye tissues will help to diagnose eye diseases earlier than current methods.

Diurnal Optic Nerve Head Perfusion in Normal and Glaucoma Eyes

Optical Coherence Tomography (OCT) microangiography is an imaging technique that is used to study the blood flow of the eye. Blood flow to the optic nerve of the eye can be affected by blood pressure and eye pressure and both blood pressure and eye pressure fluctuate throughout the day.  The goal of this study is to better understand whether fluctuations of blood pressure and eye pressure affect the OCT microangiography images acquired throughout the day.

Macular Telangiectasia (MacTel) and The Natural History Observation Registry (NHOR)

MacTel is an age related eye disorder that causes gradual deterioration of central vision. It is a disease of the retina, the light sensing tissue at the back of the eye. The worldwide MacTel Project aims to improve the clinical understanding of MacTel, raise awareness of the disease, and identify causes and appropriate treatments. 

The Natural History Observation Registry (NHOR) is a world-wide registry of individuals with Macular Telangiectasia type 2, and their family members. Enrollment in the registry involves an initial clinic visit with a comprehensive eye exam, and blood is drawn for MacTel research. By enrolling in the registry, individuals are helping to advance MacTel research.

HUMBOLDT STUDY - Clinical Research Study Evaluating an Investigational Drug in Participants with Active Noninfectious Uveitis

This study is about evaluating an oral investigational drug in subjects with noninfectious uveitis. Having a better understanding on how this investigational drug blocks specific pathways may be important to the type of eye inflammation that leads to uveitis.  This study will examine whether this investigational drug can potentially control this inflammation over time so flares of uveitis are avoided. This will happen as a standard steroid therapy is slowly discontinued. For additional information please visit clinicaltrials.gov.

Ceclia Lee

Cecilia S. Lee, M.D.

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Program Information

For more information:

Clinicaltrials.gov
Participate in Research
Human Subject Division - Research Participant