Dr. Pepple grew up in Dallas, TX. She earned her bachelor’s degree from the University of Oklahoma. She completed an MD/PhD program at Baylor College of Medicine, earning a PhD in Genetics. Following transitional internship at The Methodist Hospital in Houston, she completed her residency in ophthalmology and a medical retina fellowship at Duke University.

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Overview

Undergraduate Education: BS, Microbiolology, University of Oklahoma, 1997

Medical School: MD, Baylor College of Medicine, 2008

Post Graduate Education: PhD, Baylor College of Medicine, 2006

Internship: Transitional year, The Methodist Hospital, 2009

Residency: Ophthalmology, Duke University, 2012

Fellowships: Medical Retina, Duke University, 2013

                  Uveitis, University of Washington, 2014 

Board Certification: American Board of Ophthalmology,2013

Memberships: American Academy of Ophthalmology (AAO)    

                    Association for Research in Vision and Ophthalmology (ARVO)

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Clinical Interests

Dr. Pepple specializes in uveitis, including iritis, pars planitis, retinitis, choroiditis and scleritis, and medical retinal disease including age related macular degeneration, diabetic retinopathy, and retinal vascular diseases.

Research & Focus

Dr. Pepple’s laboratory is interested in understanding the pathogenesis of ocular inflammation, and developing new therapies to treat patients with uveitis. Her lab is also interested in novel applications of advanced imaging modalities such as optical coherence tomography (OCT) and IVIS in clinical and pre-clinical studies of uveitis.

Awards & Honors

2017    Research to Prevent Blindness Career Development Award

2017    Alcon Research Institute Young Investigator Award

2015    Latham Vision Science Innovation Award

2014    NIH NEI K08 grant recipient

2014    Federation of Clinical Immunology Societies Travel Award

2014    American Uveitis Society Fellow Travel Grant

2013    Heed Ophthalmic Foundation Fellowship award

Publications

Pepple KL, Chu Z, Weinstein J, Munk MR, Van Gelder RN, Wang RK. JAMA Ophthalmol. Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy. JAMA Ophthalmology 2018 Nov 1;136(11):1288-1292. PMID:30128478

Pepple KL, Lin P. Targeting Interleukin-23 in the Treatment of Noninfectious Uveitis. Ophthalmology. 2018 Dec;125(12):1977-1983. Epub 2018 Jul 4. Review. PMID: 30458922

Pepple, KL, Wilson, L. Van Gelder, RN. Comparative flow cytometry from the aqueous and vitreous of individual eyes in two experimental uveitis models. Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2504-2511. PMID: 29847657

Choi WJ, Pepple KL, Wang RK. Automated 3-D cell counting method for grading uveitis of rodent eye in vivo with optical coherence tomography. Journal of Biophotonics. 2018 May 24:e201800140. PMID:29797544

Weinstein J., Pepple KL. Cytokines in Uveitis. Current Opinions in Ophthalmology. 2018 May; 29(3):267-274. PMID: 29521875

Pepple KL, Nguyen MH, Pakzad-Vaezi K, Williamson K, Odell N, Lee C, Leveque TK, Van Gelder RN. Response of Uveitic Cystoid Macular Edema to Treatment with Oral Acetazolamide. Retina 2018 PMID: 29346240

Pakzad-Vaezi K, Khaksari K, Chu Z, Van Gelder RN, Wang RK, Pepple KL. Swept-Source OCT Angiography of Serpiginous Choroiditis. Ophthalmol Retina. 2018 Jul;2(7):712-719. Epub 2017 Dec 29. PMID:30148243        

Chu Z, Chen CL, Zhang Q, Pepple K, Durbin M, Gregori G, Wang RK.. Complex signal-based OCT angiography enables in vivo visualization of choriocapillaris in human choroid. J Biomed Opt. 2017 Nov;22(12):1-10. PMID: 29178697

Bajema KL, Pakzad-Vaezi K, Hawn T, Pepple KL. Tuberculous uveitis in a low endemic setting: association between anti-tuberculosis therapy and clinical response in a non-endemic country. J Ophthalmic Inflamm Infect. 2017 Oct 4;7(1):19. PMID: 28980216

Pakzad-Vaezi K, Pepple KL. Tubulointerstitial Nephritis and Uveitis. Current Opinions in Ophthalmology. 2017 Nov;28(6):629-635.  PMID: 2880618

Gutowski MB, Wilson L, Van Gelder RN, Pepple KL. In Vivo Bioluminescence Imaging for Longitudinal Monitoring of Inflammation in Animal Models of Uveitis. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3): 1521-1528. PubMed PMID: 28278321

Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani AH. Quantifying retinal microvascular changes in uveitis using spectral domain optical coherence tomography angiography (SD-OCTA). AM J Ophthalmol. 2016 Sep 1. PMID 27594138

Pepple KL, Choi WJ, Wilson L, Van Gelder RN, Wang RK. Quantitative assessment of anterior segment inflammation in a rat model of uveitis using spectral domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2016 Jul 1;57(8):3567-75. PMID 27388049

Zhang Q, Lee CS, Chao J, Chen CL, Zhang T, Sharma U, Zhang A, Liu J, Rezaei K, Pepple KL, Munsen R, Kinyoun J, Johnstone M, Van Gelder RN, Wang RK. Wide-field optical coherence tomography based microangiography for retinal imaging. Sci Rep. 2016 Feb 25;6:22017. PMID: 26912261

Pepple KL, Rotkis L, Van Grol J, Wilson L, Sandt A, Lam DL, Carlson E, Van Gelder RN. (2015) Primed Mycobacterial Uveitis (PMU): Histologic and Cytokine Characterization of a Model of Uveitis in Rats. Invest Ophthalmol Vis Sci. Dec 1:56(13):8438-48. doi: 10.1167/iovs.15-17523. PubMed PMID: 26747775

Pepple KL, Rotkis L, Wilson L, Sandt A, Van Gelder RN. (2015) Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats. Invest Ophthalmol Vis Sci. Dec 1:56(13):8449-56. doi: 10.1167/iovs.15-17524. PubMed PMID: 26747776

 

 

CONTACT INFO

Primary Clinical Office

Eye Institute at Harborview

Location
Harborview Medical Center
908 Jefferson St., 7th Floor
Seattle, WA
Clinic Phone: 206-744-2020
Clinic Fax: 206-897-4320

Mailing Address:
Box 359608
325 Ninth Ave.
Seattle, WA 98104
Academic Phone: 206-543-7250

Additional Offices

UW Medicine – Vision Science Center

South Lake Union

Location:
Box 355058

750 Republican St., Bldg. E
Seattle, WA 98108
Phone: 206-543-7250
Fax: 206-685-9315

Mailing Address:
Vision Science Center

Box 358058
750 Republican St., Bldg. E
Seattle, WA 98108

 

 

Languages

English

Lab

UW Medicine – Vision Science Center

South Lake Union