• Dec122019

    Carla Green, PhD
    Professor in Department of Neuroscience
    UT Southwestern, Dallas

    Time: 1:30 pm, Thursday
    Dec 12, 2019

    Location: Orin Smith Auditorium, SLU C

    To schedule an appointment please email Dr. Maureen Neitz.

    The Green Lab studies the molecular mechanism of circadian timing in mammals, with a particular interest in transcriptional and post-transcriptional regulatory mechanisms. A major focus of the Green Lab is the protein encoded by the Nocturnin gene. Nocturnin is a magnesium-dependent ribonuclease that specifically degrades mRNA polyA tails, suggesting that it plays a role in post-transcriptional regulation of circadian gene expression. Dr. Green’s hypothesis is that Nocturnin acts on specific circadian-relevant mRNAs and that it recognizes these RNAs via interaction with specific RNA-binding proteins Her lab is trying to identify these RNA targets and to determine the mechanism by which Nocturnin regulates their expression, as well as determining more broadly the role that post-transcriptional regulatory mechanisms play in exerting circadian control of behavior and physiology. 

    Nocturnin knockout mice have a striking metabolic phenotype – they are resistant to diet-induced obesity and hepatic steatosis, and have altered glucose and lipid metabolism. The Green lab is studying the mechanism behind the lean phenotype of the Nocturnin knockout mice and to further delineate the role of the circadian clock in control of metabolic homeostasis.

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