Dr. Buhr earned his Ph.D. in 2008 studying neuroscience at Northwestern University in the laboratory of Dr. Joseph Takahashi. He completed his postdoctoral training at the University of Washington with Dr. Russell Van Gelder from 2009-2015.

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Undergraduate Education:          BA, Biology, University of St. Thomas, 2000

Graduate Education:                     PhD, Neuroscience, Northwestern University, 2008

Post-Doctoral Education:            Senior Fellow, Dept. Ophthalmology University of

                                                              Washington 2009-2014       


  • Association for Research in Vision and Ophthalmology (ARVO)
  • Optical SocietyofAmerica (OSA)
  • Society for Researchon Biological Rhythms (SRBR)


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Research in the Buhr laboratory focuses on circadian rhythms of the retina and other ocular tissues.  A major focus area is the mechanisms by which circadian clocks within the eye become synchronized by light.

2011              Ruth L. Kirschstein National Research Service Award for Postdoctoral


2010              Postdoctoral Award: Fight for Sight

2008              Research Merit Award: Society for Researchon Biological Rhythms

Buhr ED, Yue WW, Ren X, Jiang Z, Liao HW, Mei X, Vemaraju S, Nguyen MT, Reed RR, Lang RA, Yau KW, Van Gelder RN (2015) Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea.  Proc Natl Acad SciUSA112(42): 13093-8 


Buhr ED and Van Gelder RN.(2014) Local photic entrainment of the retinal circadian oscillator in the absence of rods, cones, and melanopsin. Proc Natl Acad SciUSA111(23): 8625-30.

Owens L, Buhr E, Tu DC, Lamprecht TL, Lee J, Van Gelder RN.(2012) Effect of circadian clock gene mutations on nonvisual photoreception in the mouse. Invest Ophthalmol VisSci53(1): 454-60.

Buhr EDYoo SY, and Takahashi JS. (2010) Temperature as a universal resetting cue for mammalian circadian oscillators. Science 330(6002): 379-85

Marcheva B, Ramsey KM ,Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBaileyL, Wang X, Takahashi JS, Bass J. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466(7306): 627-3


Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr EDLee C, Takahashi JS,Imai S,Bass J. (2009) Circadian clock feedback cycle through NAMPT-mediated NAD+biosynthesis. Science 324(5927): 651-4.


Book Chapters:

Buhr ED&Takahashi JS.(2013) Genetic control of the circadian pacemaker. The Genetic Basis of Sleep and Sleep Disorders. Cambridge UniversityPress: 119-126.

Buhr ED &Takahashi JS.(2013) Molecular components of the mammalian circadian clock.

Handbook of Experimental Pharmacology.(217): 3-27.


Review Articles:

Van Gelder RN & Buhr ED (2016) Ocular Photoreception for Circadian Rhythm Entrainment in Mammals. Annu Rev Vis Sci 2:12.1-12.17

Buhr Van Gelder RN. (2014) The Making of the Master Clock. Elife Aug20; 3:e04014.

         Sexton T, Buhr E, and Van Gelder RN.(2012) Melanopsin and mechanisms of non-visual        ocularphotoreception.  J Biol Chem 287(3): 1649-56.



UW Medicine - Vision Science Center



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Vision Science Center
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Vision Research Scientist